Quinolines and derivatives

Medchemexpress LLC Ethanamine, 2-(2-methoxyethoxy)- | 31576-51-9 | 99.9% | 119.16 | C5H13NO2 | 500 MG

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m-PEG2-Amine is a methoxy-terminated polyethylene glycol (PEG) linker that provides a short PEG2 spacer with a terminal primary amine for conjugation. It is used as a cleavable linker in antibody-drug conjugate (ADC) synthesis and as a PEG-based linker in proteolysis-targeting chimera (PROTAC) construction.

• Short PEG spacer with terminal primary amine for conjugation chemistry.
• High purity (99.9% by GC) suitable for research applications.
• Molecular weight 119.16 and formula C5H13NO2.
• Available in small lab quantities, e.g., 500 MG.
• Recommended storage: 4°C, protect from light; in solvent store at -80°C for long-term.

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Medchemexpress LLC m-PEG11-amine | 854601-60-8 | 515.64 g/mol | C23H49NO11 | 100 MG

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m-PEG11-amine is a PEG-based linker bearing a terminal amine used as a cleavable linker in antibody-drug conjugates (ADCs) and as a PROTAC linker or PEG spacer in conjugation chemistry. It provides a water-soluble spacer that facilitates conjugation to activated esters, carboxylic acids, and other reactive groups, improving solubility and flexibility of the resulting bioconjugates.

• PEG-based linker with a terminal primary amine for conjugation
• Used as a cleavable linker in antibody-drug conjugates (ADCs)
• Suitable as a PROTAC linker or PEG spacer in conjugation chemistry
• Water-soluble spacer improves solubility and flexibility of conjugates
• Available in multiple sizes for research-scale synthesis

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Medchemexpress LLC Dibenzocyclooctyne-amine | 1255942-06-3 | MFCD22380759 | 99.1% | 276.34 | C18H16N2O | 1 G

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DBCO-amine is a dibenzocyclooctyne-functionalized amine reagent used for copper-free click chemistry (strain-promoted alkyne-azide cycloaddition, SPAAC). It is supplied at high purity for bioconjugation and linker synthesis, and is suitable for labeling azide-bearing biomolecules.

• Enables copper-free SPAAC bioconjugation with azide groups
• High purity suitable for synthetic and bioconjugation workflows
• Available in multiple pack sizes, including 1 g for scale-up
• Used for ADC linker synthesis and labeling applications
• Soluble in common organic solvents such as DMSO

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Medchemexpress LLC Amino-PEG8-amine | 82209-36-7 | 98.0% | 500 MG

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Amino-PEG8-amine is a PEG-based (8 units) PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• Appears as liquid
• Color is colorless to light yellow
• Molecular weight: 412.52
• Molecular formula: C18H40N2O8
• CAS number: 82209-36-7
• Purity: 98.0%
• Store at 4°C, protected from light
• In solvent, store at -80°C for 6 months or -20°C for 1 month (protected from light)
• Soluble in DMSO at 100 mg/mL

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Medchemexpress LLC TLR7/8 agonist 1 dihydrochloride | 1620278-72-9 | MFCD31657341 | 99.7% | 432.39 | C22H27Cl2N5 | 10 MG

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TLR7/8 agonist 1 dihydrochloride is a small-molecule imidazoquinoline research compound that acts as a dual agonist of Toll-like receptors 7 and 8. It is intended for use in immunology and inflammation studies and demonstrates low-nanomolar activity in receptor assays, suitable for both in vitro and in vivo experimental applications.

• Dual agonist of TLR7 and TLR8 with low-nanomolar potency.
• High reported purity (99.7%).
• Molecular weight 432.39 and formula C22H27Cl2N5.
• High solubility in DMSO (83.33 mg/mL) and compatible with common in vivo vehicles.
• Supplied as an off-white to light yellow solid and available as a DMSO solution.
• Storage: 4°C sealed; in solvent store at -80°C for long term.

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Medchemexpress LLC Amino-PEG5-amine | 72236-26-1 | 97.0% | 10 G

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